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生物节律与长寿的关系

浏览:9696 来源:Aging Cell
 

    近日,来自麻省理工学院(MIT)的科学家在Aging Cell发表了题为“Deviation of innate circadian period from 24 hours reduces longevity in mice.”的研究论文。在该研究中,Guarente及其同事发现,近日节律接近24小时的小鼠较其他小鼠的寿命要长20%。该研究表明维持一个24小时的生物节律是长寿的一个重要指标。因此,有可能通过检测生物节律来预测长寿。另一方面,干扰生物节律(例如,没有规律的生活作息)可能影响长寿。

 

杂志:Aging Cell. 2012 Jun 15. doi: 10.1111/j.1474-9726.2012.00846.x.

题目:Deviation of innate circadian period from 24 hours reduces longevity in mice

作者:Libert S, Bonkowski MS, Pointer K, Pletcher SD, Guarente L.

单位:Paul F. Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA; Department of Molecular and Integrative Physiology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109, USA.

摘要:The variation of individual lifespans, even in highly inbred cohorts of animals and under strictly controlled environmental conditions, is substantial and not well understood. This variation in part could be due to epigenetic variation, which later affects the animal's physiology and ultimately longevity. Identification of the physiological properties that impact health and lifespan is crucial for longevity research and the development of anti-aging therapies. Here we measured individual circadian and metabolic characteristics in a cohort of inbred F1 hybrid mice and correlated these parameters to their lifespans. We found that mice with innate circadian periods close to 24 hours (revealed during 30 days of housing in total darkness) enjoyed nearly 20% longer lifespans than their littermates, which had shorter or longer innate circadian periods. These findings show that maintenance of a 24 hour intrinsic circadian period is a positive predictor of longevity. Our data suggest that circadian period may be used to predict individual longevity and that processes that control innate circadian period affect aging.

     
     
     
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