中 文 English 欢迎您,请登录 | 还没帐号?请注册 
 

 

新闻资讯

> 首页 > 新闻资讯 > 科技动态 > 正文
通知公告实验室新闻科技动态
 

大脑老化与基因相关

浏览:7544 来源:Biology News Net
 

For the first time in a large study sample, the decline in brain function in normal aging is conclusively shown to be influenced by genes, say researchers from the Texas Biomedical Research Institute in San Antonio and Yale University.


"Identification of genes associated with brain aging should improve our understanding of the biological processes that govern normal age-related decline," said John Blangero, Ph.D., a Texas Biomed geneticist and the senior author of the paper. The study, funded by the National Institutes of Health (NIH), is published in the November 4, 2013 issue of the Proceedings of the National Academy of Sciences. David Glahn, Ph.D., an associate professor of psychiatry at the Yale University School of Medicine, is the first author on the paper.


In large pedigrees including 1,129 people aged 18 to 83, the scientists documented profound aging effects from young adulthood to old age, on neurocognitive ability and brain white matter measures. White matter actively affects how the brain learns and functions. Genetic material shared amongst biological relatives appears to predict the observed changes in brain function with age.


Participants were enrolled in the Genetics of Brain Structure and Function Study and drawn from large Mexican Americans families in San Antonio. Brain imaging studies were conducted at the University of Texas Health Science Center at San Antonio Research Imaging Institute directed by Peter Fox, M.D.


"The use of large human pedigrees provides a powerful resource for measuring how genetic factors change with age," Blangero said. By applying a sophisticated analysis, the scientists demonstrated a heritable basis for neurocognitive deterioration with age that could be attributed to genetic factors. Similarly, decreasing white matter integrity with age was influenced by genes., The investigators further demonstrated that different sets of genes are responsible for these two biological aging processes.


"A key advantage of this study is that we specifically focused on large extended families and so we were able to disentangle genetic from non-genetic influences on the aging process," said Glahn.


Source : jcarey@txbiomed.org

     
     
     
    中南大学 | 湘雅医学院 | 生命科学学院 | 网站地图 | 联系我们 | 支持我们
     
     
    Copyright © 医学遗传学重点实验室
    湘ICP备05006191号 · 湘教QS3-200505-000576

    电话:0731-84472093 传真:0731-84478152 邮编:410078
    地址:中国湖南长沙市湘雅路110号 医学遗传学重点实验室

    访问统计:466798